Development of Subject Specific Finite Element Models of the Mouse Knee Joint for Preclinical Applications.

ABSTRACT: Osteoarthritis is the most common musculoskeletal disabling disease worldwide. Preclinical studies on mice are commonly performed to test new interventions. Finite element (FE) models can be used to study joint mechanics, but usually simplified geometries are used. The aim of this project was to create a realistic subject specific FE model of the mouse knee joint for the assessment of joint mechanical properties. Four different FE models of a C57Bl/6 female mouse knee joint were created based on micro-computed tomography images of specimens stained with phosphotungstic acid in order to include different features: individual cartilage layers with meniscus, individual cartilage layers without meniscus, homogeneous cartilage layers with two different thickness values, and homogeneous cartilag

SUBMITTER: Zanjani-Pour S 

PROVIDER: S-EPMC7593650 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature