Foxp3+ Regulatory T Cells Inhibit CCl₄-Induced Liver Inflammation and Fibrosis by Regulating Tissue Cellular Immunity.

ABSTRACT: Foxp3+ regulatory T (Treg) cells are pivotal in maintaining immunological self-tolerance and tissue homeostasis; however, it remains unclear how tissue Treg cells respond to liver injury and regulate chronic inflammation, which can cause liver fibrosis. We report here that hepatic Treg cells play a critical role in preventing liver pathology by suppressing inflammatory cellular immunity that can promote liver damage and fibrosis. Chronic liver inflammation induced by injections of carbon tetrachloride (CCl₄) led to preferential expansion of hepatic Treg cells that prevented liver fibrosis. In contrast, depletion of Treg cells in the CCl₄-induced liver fibrosis model exacerbated the severity of liver pathology. Treg depletion unleashed tissue cellular immunity and drov

SUBMITTER: Ikeno Y 

PROVIDER: S-EPMC7593684 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature