Spectrum of Mesenchymal-Epithelial Transition Aberrations and Potential Clinical Implications: Insights From Integrative Pancancer Analysis.

ABSTRACT:

Background

The receptor tyrosine kinase mesenchymal-epithelial transition factor (MET) is frequently altered in cancers and is a common therapeutic target for cancers with MET variants. However, abnormal MET alterations and their associations with patient outcome across different cancer types have not been studied simultaneously. In this study, we try to fill the vacancy in a comprehensive manner and capture the full MET alteration spectrum.

Methods

A total of 10,967 tumor samples comprising 32 cancer types from The Cancer Genome Atlas (TCGA) datasets were analyzed for MET abnormal expression, mutations, and copy number variants (CNVs).

Results

MET abnormal expression, alteration frequency, mutation site distribution, and functional impact varied across different canc

SUBMITTER: Li J 

PROVIDER: S-EPMC7593712 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature