Age and environmental exposures influence the fecal bacteriome of young children with cystic fibrosis.

ABSTRACT:

Background

Mechanisms that facilitate early infection and inflammation in cystic fibrosis (CF) are unclear. We previously showed that young CF children with secondhand smoke exposure (SHSe) have increased susceptibility to respiratory infections. We aimed to define the impact of SHSe and other external factors upon the fecal bacteriome in early CF.

Methods

Twenty CF infants and children were enrolled, clinical data recorded, and hair nicotine measured as an objective surrogate of SHSe. Fecal samples were collected at clinic visits and bacteriome 16S rRNA gene sequencing performed.

Results

SHSe was associated with increased alpha diversity and increased relative abundance of Acinetobacter and Akkermansia, along with decreased Bifidobacterium and Lactobacillus. Recent a

SUBMITTER: Loman BR 

PROVIDER: S-EPMC7593804 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature