Value of Coronary Artery Calcium Scanning in Association With the Net Benefit of Aspirin in Primary Prevention of Atherosclerotic Cardiovascular Disease.

ABSTRACT:

Importance

Higher coronary artery calcium (CAC) identifies individuals at increased atherosclerotic cardiovascular disease (ASCVD) risk. Whether it can also identify individuals likely to derive net benefit from aspirin therapy is unclear.

Objective

To examine the association between CAC, bleeding, and ASCVD and explore the net estimated effect of aspirin at different CAC thresholds.

Design, setting, and participants

Prospective population-based cohort study of Dallas Heart Study participants, free from ASCVD and not taking aspirin at baseline. Data were analyzed between February 1, 2020, and July 15, 2020.

Exposures

Coronary artery calcium score in the following categories: 0, 1-99, and 100 or higher.

Main outcomes and measures

Major bleeding and ASCVD

SUBMITTER: Ajufo E 

PROVIDER: S-EPMC7593878 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature