Vascular tone and angiogenesis modulation by catecholamine coordinated to ruthenium.

ABSTRACT: Catecholamines participate in angiogenesis, an important tumor development process. However, the way catecholamines interact with their receptors has not been completely elucidated, and doubts still remain as to whether these interactions occur between catechol and/or amine sites and particular amino acid residues on the catecholamine receptors. To evaluate how catechol and amine groups contribute to angiogenesis, we immobilized the catechol site through ruthenium ion (Ru) coordination, to obtain species with the general formula [Ru(NH₃)₄(catecholamine-R)]Cl. We then assessed the angiogenic activity of the complexes in a chorioallantoic membrane model (CAM) and examined vascular reactivity and calcium mobilization in rat aortas and vascular cells. [Ru(NH₃)<

SUBMITTER: Alves JQ 

PROVIDER: S-EPMC7593891 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature