A Methylation-Based Reclassification of Bladder Cancer Based on Immune Cell Genes.

ABSTRACT: Bladder cancer is highly related to immune cell infiltration. This study aimed to develop a new classification of BC molecular subtypes based on immune-cell-associated CpG sites. The genes of 28 types of immune cells were obtained from previous studies. Then, methylation sites corresponding to immune-cell-associated genes were acquired. Differentially methylated sites (DMSs) were identified between normal samples and bladder cancer samples. Unsupervised clustering analysis of differentially methylated sites was performed to divide the sites into several subtypes. Then, the potential mechanism of different subtypes was explored. Bladder cancer patients were divided into three groups. The cluster 3 subtype had the best prognosis. Cluster 1 had the poorest prognosis. The distribution of immun

SUBMITTER: Luo Q 

PROVIDER: S-EPMC7593922 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature