Characterization of Asparagine Deamidation in Immunodominant Myelin Oligodendrocyte Glycoprotein Peptide Potential Immunotherapy for the Treatment of Multiple Sclerosis.

ABSTRACT: Mannan (polysaccharide) conjugated with a myelin oligodendrocyte glycoprotein (MOG) peptide, namely (KG)₅MOG_35-55, represents a potent and promising new approach for the immunotherapy of Multiple Sclerosis (MS). The MOG_35-55 epitope conjugated with the oxidized form of mannan (poly-mannose) via a (KG)₅ linker was found to inhibit the symptoms of MOG_35-55-induced experimental autoimmune encephalomyelitis (EAE) in mice using prophylactic and therapeutic vaccinated protocols. Deamidation is a common modification in peptide and protein sequences, especially for Gln and Asn residues. In this study, the structural solution motif of deaminated peptides and their functional effects in an animal model for MS were explored. Several peptides base

SUBMITTER: Androutsou ME 

PROVIDER: S-EPMC7593956 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature