Effects of age on electrophysiological measures of cochlear synaptopathy in humans.

ABSTRACT: Age-related cochlear synaptopathy (CS) has been shown to occur in rodents with minimal noise exposure, and has been hypothesized to play a crucial role in age-related hearing declines in humans. Because CS affects mainly low-spontaneous rate auditory nerve fibers, differential electrophysiological measures such as the ratio of the amplitude of wave I of the auditory brainstem response (ABR) at high to low click levels (WI_H/WI_L), and the difference between frequency following response (FFR) levels to shallow and deep amplitude modulated tones (FFR_S-FFR_D), have been proposed as CS markers. However, age-related audiometric threshold shifts, particularly prominent at high frequencies, may confound the interpretation of these measures in cross-section

SUBMITTER: Carcagno S 

PROVIDER: S-EPMC7593961 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature