A CozE Homolog Contributes to Cell Size Homeostasis of Streptococcus pneumoniae.

ABSTRACT: Control of peptidoglycan assembly is critical to maintain bacterial cell size and morphology. Penicillin-binding proteins (PBPs) are crucial enzymes for the polymerization of the glycan strand and/or their cross-linking via peptide branches. Over the last few years, it has become clear that PBP activity and localization can be regulated by specific cognate regulators. The first regulator of PBP activity in Gram-positive bacteria was discovered in the human pathogen Streptococcus pneumoniae This regulator, named CozE, controls the activity of the bifunctional PBP1a to promote cell elongation and achieve a proper cell morphology. In this work, we studied a previously undescribed CozE homolog in the pneumococcus, which we named CozEb. This protein displays the same membrane organizatio

SUBMITTER: Stamsas GA 

PROVIDER: S-EPMC7593971 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature