A Small-Molecule Modulator of Metal Homeostasis in Gram-Positive Pathogens.

ABSTRACT: Metals are essential nutrients that all living organisms acquire from their environment. While metals are necessary for life, excess metal uptake can be toxic; therefore, intracellular metal levels are tightly regulated in bacterial cells. Staphylococcus aureus, a Gram-positive bacterium, relies on metal uptake and metabolism to colonize vertebrates. Thus, we hypothesized that an expanded understanding of metal homeostasis in S. aureus will lead to the discovery of pathways that can be targeted with future antimicrobials. We sought to identify small molecules that inhibit S. aureus growth in a metal-dependent manner as a strategy to uncover pathways that maintain metal homeostasis. Here, we demonstrate that VU0026921 kills S. aureus through disruption of metal h

SUBMITTER: Juttukonda LJ 

PROVIDER: S-EPMC7593973 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature