Estimation of Full-Length TprK Diversity in Treponema pallidum subsp. pallidum.

ABSTRACT: Immune evasion and disease progression of Treponema pallidum subsp. pallidum are associated with sequence diversity in the hypervariable outer membrane protein TprK. Previous attempts to study variation within TprK have sequenced at depths insufficient to fully appreciate the hypervariable nature of the protein, failed to establish linkage between the protein's seven variable regions, or were conducted on isolates passed through rabbits. As a consequence, a complete profile of tprK during infection in the human host is still lacking. Furthermore, prior studies examining how T. pallidum subsp. pallidum uses its repertoire of genomic donor sites to generate diversity within the variable regions of the tprK have yielded a partial understanding of this

SUBMITTER: Addetia A 

PROVIDER: S-EPMC7593977 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature