Synthesis and Stability of Actinium-225 Endohedral Fullerenes, ²²⁵Ac@C₆₀.

ABSTRACT: We report the first synthesis of ²²⁵Ac (t _1/2 = 10 days) endohedral fullerenes,²²⁵Ac@C₆₀. The ²²⁵Ac@C₆₀ was produced with a 12 ± 2% efficiency by applying an electrical arc discharge between a source of α-particle emitter ²²⁵Ac (∼1 mCi, electroplated on a Pt disk) and a thin coat of "preformed" C₆₀ on an Al disk (C₆₀ thickness of ∼0.25 mg/cm²). After formation by electrical arc discharge, the resulting radiofullerenes on the Al disk were dissolved in toluene under anaerobic conditions and converted to a malonate derivative using the Bingel reaction. Subsequent to repeated washings of the organic phase with dilute acidic solutions to remove exohedral ²²⁵Ac, ∼45% of

SUBMITTER: Mwakisege JG 

PROVIDER: S-EPMC7594009 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature