Nature of Metal-Drug Bond in Some Antitumor Active Complexes of Coinage Metal Ions.

ABSTRACT: N-Heterocyclic carbene and phosphine can be labeled as solid σ-donor ligands and can contribute to stable complexes. In addition, the constructed complex can accommodate a wide variety of applications, such as pharmaceutical products. In the light of this, a theoretical analysis was carried out on the existence of metal-drug interactions of group 11 metal ions in coordination with symmetrical unsaturated N-heterocyclic carbenes [NHC(R)(R')] and monodentate phosphine (PR₃). The R substitutes on N atoms in NHC and phosphines are identical, and R' substitutes are located on two noncarbenic carbon atoms (C4 and C5) in the heterocycle complexes. All complexes are in general formula, [Tgt → ML] {where M = Cu(I), Ag(I), Au(I), Tgt = 2,3,4,6-tetra-O-acetyl-1-thio-β-d-glucopyranos

SUBMITTER: Naderizadeh B 

PROVIDER: S-EPMC7594011 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature