rad21 Is Involved in Corneal Stroma Development by Regulating Neural Crest Migration.

ABSTRACT: Previously, we identified RAD21^R450C from a peripheral sclerocornea pedigree. Injection of this rad21 variant mRNA into Xenopus laevis embryos disrupted the organization of corneal stroma fibrils. To understand the mechanisms of RAD21-mediated corneal stroma defects, gene expression and chromosome conformation analysis were performed using cells from family members affected by peripheral sclerocornea. Both gene expression and chromosome conformation of cell adhesion genes were affected in cells carrying the heterozygous rad21 variant. Since cell migration is essential in early embryonic development and sclerocornea is a congenital disease, we studied neural crest migration during cornea development in X. laevis embryos. In X. laevis embryos inj

SUBMITTER: Zhang BN 

PROVIDER: S-EPMC7594026 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature