Application of a Colorimetric and Near-Infrared Fluorescent Probe in Peroxynitrite Detection and Imaging in Living Cells.

ABSTRACT: Peroxynitrite (ONOO^-) plays a vital role in pathological and physiological processes, and an excessive amount of ONOO^- causes various diseases. Developing a specific and sensitive method for the detection of ONOO^- in biological systems is significant. Herein, we reported a novel colorimetric and near-infrared fluorescent probe (pyridin-4-ylmethyl (Z)-2-cyano-2-(3-((E)-4-hydroxystyryl)-5,5-dimethylcyclohex-2-en-1-ylidene)acetate diphenyl phosphinate group (AN-DP)) based on isophorone and phosphinate groups for ONOO^- detection. The probe displayed excellent selectivity toward ONOO^- compared with other relevant analytes. It showed a good linear relationship between the fluorescence intensity at 670 nm and ONOO^- concentra

SUBMITTER: Gu B 

PROVIDER: S-EPMC7594142 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature