Phenotypic and proteomic approaches of the response to iron-limited condition in Staphylococcus lugdunensis.

ABSTRACT:

Background

Staphylococcus lugdunensis is a coagulase-negative Staphylococcus part of the commensal skin flora but emerge as an important opportunistic pathogen. Because iron limitation is a crucial stress during infectious process, we performed phenotypic study and compared proteomic profiles of this species incubated in absence and in presence of the iron chelator 2,2'-dipyridyl (DIP).

Results

No modification of cell morphology nor cell wall thickness were observed in presence of DIP. However iron-limitation condition promoted biofilm formation and reduced the ability to cope with oxidative stress (1 mM H₂O₂). In addition, S. lugdunensis N920143 cultured with DIP was significantly less virulent in the larvae of Galleria mellonella model of infection th

SUBMITTER: Aubourg M 

PROVIDER: S-EPMC7594282 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature