Inbreeding depression across the genome of Dutch Holstein Friesian dairy cattle.

ABSTRACT:

Background

Inbreeding depression refers to the decrease in mean performance due to inbreeding. Inbreeding depression is caused by an increase in homozygosity and reduced expression of (on average) favourable dominance effects. Dominance effects and allele frequencies differ across loci, and consequently inbreeding depression is expected to differ along the genome. In this study, we investigated differences in inbreeding depression across the genome of Dutch Holstein Friesian cattle, by estimating dominance effects and effects of regions of homozygosity (ROH).

Methods

Genotype (75 k) and phenotype data of 38,792 cows were used. For nine yield, fertility and udder health traits, GREML models were run to estimate genome-wide inbreeding depression and estimate additive, dominanc

SUBMITTER: Doekes HP 

PROVIDER: S-EPMC7594306 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature