Local and distant tumor dormancy during early stage breast cancer are associated with the predominance of infiltrating T effector subsets.

ABSTRACT:

Background

Although breast cancer mortality is a result of distant recurrences associated with the establishment of tumor dormancy, current clinical practice guidelines recommend a wait and watch approach for tumor recurrences. This is because of our limited understanding of tumor dormancy and insufficient evidence in support of immunological control of tumor dormancy.

Methods

We used FVBN202 transgenic mice expressing rat neu oncogene in the mammary glands, and their parental FVB strain lacking neu expression. These models allowed the detection of tumor dormancy at distant sites using the rat neu protein as a tumor marker. We also used Ki67 for the detection of the indolent and quiescent types of tumor dormancy. Multicolor flow cytometry was used to detect dormant tumor cel

SUBMITTER: Aqbi HF 

PROVIDER: S-EPMC7594332 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature