Dataset Information
Safety and Efficacy of Imatinib for Hospitalized Adults with COVID-19: A structured summary of a study protocol for a randomised controlled trial.
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ABSTRACT:
SUBMITTER: Emadi A
PROVIDER: S-EPMC7594416 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Publications
Safety and Efficacy of Imatinib for Hospitalized Adults with COVID-19: A structured summary of a study protocol for a randomised controlled trial.
Trials 20201028 1
<h4>Objectives</h4>Primary Objective: To evaluate the efficacy and safety of oral administration of imatinib combined with the Best Conventional Care (BCC) versus placebo plus BCC in hospitalized patients with COVID-19.<h4>Hypothesis</h4>Addition of imatinib to the BCC will provide a superior clinical outcome for patients with COVID-19 compared with BCC plus placebo. This hypothesis is on the basis of 1) intralysosomal entrapment of imatinib will increase endosomal pH and effectively decrease SA ...[more]