Increased E2F2 predicts poor prognosis in patients with HCC based on TCGA data.

ABSTRACT:

Background

The E2F family of transcription factor 2 (E2F2) plays an important role in the development and progression of various tumors, but its association with hepatocellular carcinoma (HCC) remains unknown. Our study aimed to investigate the role and clinical significance of E2F2 in HCC.

Methods

HCC raw data were extracted from The Cancer Genome Atlas (TCGA). Wilcoxon signed-rank test, Kruskal-Wallis test and logistic regression were applied to analyze the relationship between the expression of E2F2 and clinicopathologic characteristics. Cox regression and Kaplan-Meier were employed to evaluate the correlation between clinicopathologic features and survival. The biological function of E2F2 was annotated by Gene Set Enrichment Analysis (GSEA).

Results

The expression

SUBMITTER: Zeng Z 

PROVIDER: S-EPMC7594443 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature