Identification of a Novel HIF-1α-α_Mβ₂ Integrin-NET Axis in Fibrotic Interstitial Lung Disease.

ABSTRACT: Neutrophilic inflammation correlates with mortality in fibrotic interstitial lung disease (ILD) particularly in the most severe form, idiopathic pulmonary fibrosis (IPF), although the underlying mechanisms remain unclear. Neutrophil function is modulated by numerous factors, including integrin activation, inflammatory cytokines and hypoxia. Hypoxia has an important role in inflammation and may also contribute to pulmonary disease. We aimed to determine how neutrophil activation occurs in ILD and the relative importance of hypoxia. Using lung biopsies and bronchoalveolar lavage (BAL) fluid from ILD patients we investigated the extent of hypoxia and neutrophil activation in ILD lungs. Then we used ex vivo neutrophils isolated from healthy volunteers and BAL from patients with ILD and

SUBMITTER: Khawaja AA 

PROVIDER: S-EPMC7594517 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature