Treatment-induced brain tissue necrosis: a clinical challenge in neuro-oncology.

ABSTRACT: Cancer therapy-induced adverse effects on the brain are a major challenge in neuro-oncology. Brain tissue necrosis (treatment necrosis [TN]) as a consequence of brain directed cancer therapy remains an insufficiently characterized condition with diagnostic and therapeutic difficulties and is frequently associated with significant patient morbidity. A better understanding of the underlying mechanisms, improvement of diagnostic tools, development of preventive strategies, and implementation of evidence-based therapeutic practices are pivotal to improve patient management. In this comprehensive review, we address existing challenges associated with current TN-related clinical and research practices and highlight unanswered questions and areas in need of further research with the ultimate goal

SUBMITTER: Winter SF 

PROVIDER: S-EPMC7594558 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature