Long-term clinically relevant rodent model of methotrexate-induced cognitive impairment.

ABSTRACT:

Background

With the enhanced use of chemotherapy and the advent of increased patient survival rates, there are an increasing number of cancer survivors living with chemotherapy-induced cognitive impairment. A growing number of clinical studies have brought to light the association of agents like methotrexate in generating these neurological sequelae, although mechanisms remain unclear.

Methods

Here, we use a clinically relevant regimen of several cycles of methotrexate and leucovorin rescue to develop a model of chemotherapy-induced cognitive impairment, and investigate the in vivo long-term (16 mo) impact of high-dose systemic methotrexate on white matter cellular dynamics as assessed by stereology, animal behavior, and diffusion tensor imaging.

Results

Our results i

SUBMITTER: Berlin C 

PROVIDER: S-EPMC7594568 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature