The Effect of Refractive Error on Melanopsin-Driven Pupillary Responses.

ABSTRACT:

Purpose

Human and animal studies suggest that light-mediated dopamine release may underlie the protective effect of time outdoors on myopia development. Melanopsin-containing retinal ganglion cells may be involved in this process by integrating ambient light exposure and regulating retinal dopamine levels. The study evaluates this potential involvement by examining whether melanopsin-driven pupillary responses are associated with adult refractive error.

Methods

Subjects were 45 young adults (73% female, 24.1 ± 1.8 years) with refractive errors ranging from -6.33 D to +1.70 D. The RAPDx (Konan Medical) pupillometer measured normalized pupillary responses to three forms of square-wave light pulses alternating with darkness at 0.1 Hz: alternating long wavelength (red, peak at 6

SUBMITTER: Mutti DO 

PROVIDER: S-EPMC7594593 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature