Peripheral complement proteins in schizophrenia: A systematic review and meta-analysis of serological studies.

ABSTRACT:

Background

There is renewed focus on the complement system in the pathogenesis of schizophrenia. In addition to providing aetiological insights, consistently dysregulated complement proteins in serum or plasma may have clinical utility as biomarkers.

Methods

We performed a systematic literature review searching PubMed, Embase and PsycINFO for studies measuring complement system activity or complement protein concentrations in serum or plasma from patients with schizophrenia compared to controls. Random-effects meta-analyses were performed to calculate pooled effect estimates (Hedges' g standardised mean difference [SMD]) for complement proteins whose concentrations were measured in three or more studies. The review was pre-registered on the PROSPERO database (CRD42018109012)

SUBMITTER: Mongan D 

PROVIDER: S-EPMC7594643 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature