Ciprofloxacin-loaded bioadhesive hydrogels for ocular applications.

ABSTRACT: The management of corneal infections often requires complex therapeutic regimens involving the prolonged and high-frequency application of antibiotics that provide many challenges to patients and impact compliance with the therapeutic regimens. In the context of severe injuries that lead to tissue defects (e.g. corneal lacerations) topical drug regimens are inadequate and suturing is often indicated. There is thus an unmet need for interventions that can provide tissue closure while concurrently preventing or treating infection. In this study, we describe the development of an antibacterial bioadhesive hydrogel loaded with micelles containing ciprofloxacin (CPX) for the management of corneal injuries at risk of infection. The in vitro release profile showed that the hydrogel system can rel

SUBMITTER: Khalil IA 

PROVIDER: S-EPMC7594650 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature