Modeling Carbohydrate Counting Error in Type 1 Diabetes Management.

ABSTRACT: Background: The error in estimating meal carbohydrates (CHO) amount is a critical mistake committed by type 1 diabetes (T1D) subjects. The aim of this study is both to investigate which factors, related to meals and subjects, affect the CHO counting error most and to develop a mathematical model of CHO counting error embeddable in T1D patient decision simulators to conduct in silico clinical trials. Methods: A published dataset of 50 T1D adults is used, which includes a patient's CHO count of 692 meals, dietitian's estimates of meal composition (used as reference), and several potential explanatory factors. The CHO counting error is modeled by multiple linear regression, with stepwise variable selection starting from 10 candidate predictors, that is, education l

SUBMITTER: Roversi C 

PROVIDER: S-EPMC7594710 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature