Distinctive alteration in the expression of autophagy genes in Drosophila models of amyloidopathy and tauopathy.

ABSTRACT:

Background

Alzheimer's disease (AD) is one the most common types of dementia. Plaques of amyloid beta and neurofibrillary tangles of tau are two major hallmarks of AD. Metabolism of these two proteins, in part, depends on autophagy pathways. Autophagy dysfunction and protein aggregation in AD may be involved in a vicious circle. The aim of this study was to investigate whether tau or amyloid beta 42 (Aβ42) could affect expression of autophagy genes, and whether they exert their effects in the same way or not.

Methods

Expression levels of some autophagy genes, Hook, Atg6, Atg8, and Cathepsin D, were measured using quantitative PCR in transgenic Drosophila melanogaster expressing either Aβ42 or Tau R406W.

Results

We found that Hook<

SUBMITTER: Haghi M 

PROVIDER: S-EPMC7594860 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature