Ontology highlight
ABSTRACT:
SUBMITTER: Szalaj N
PROVIDER: S-EPMC7594877 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Szałaj Natalia N Godyń Justyna J Jończyk Jakub J Pasieka Anna A Panek Dawid D Wichur Tomasz T Więckowski Krzysztof K Zaręba Paula P Bajda Marek M Pislar Anja A Malawska Barbara B Sabate Raimon R Więckowska Anna A
Journal of enzyme inhibition and medicinal chemistry 20201201 1
Effective therapy of Alzheimer's disease (AD) requires treatment with a combination of drugs that modulate various pathomechanisms contributing to the disease. In our research, we have focused on the development of multi-target-directed ligands - 5-HT<sub>6</sub> receptor antagonists and cholinesterase inhibitors - with disease-modifying properties. We have performed extended <i>in vitro</i> (FRET assay) and <i>in cellulo</i> (<i>Escherichia coli</i> model of protein aggregation) studies on thei ...[more]