Impact of Clinical Outcome Measures on Placebo Response Rates in Clinical Trials for Chronic Constipation: A Systematic Review and Meta-analysis.

ABSTRACT:

Objectives

Chronic constipation (CC) is a recurrent functional bowel disorder worldwide. The purpose of this study is to examine its pooled placebo response rate and compare placebo response level in randomized controlled trials (RCTs) with different endpoint assessments.

Methods

PubMed, Cochrane Library, and Embase were electronically searched for therapeutic RCTs of CC with placebo control. Data extraction and assessment of risk of bias were performed independently by 2 reviewers. All the statistical calculation and analysis were performed using R 3.6.0. Our protocol has registered in PROSPERO with registration number: CRD42019121287.

Results

There were 46 studies included with 5,992 constipated patients allocated to the placebo arm in total. The pooled placebo resp

SUBMITTER: Chen J 

PROVIDER: S-EPMC7594913 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature