Regulation of Trpm activation and calcium wave initiation during Drosophila egg activation.

ABSTRACT: The transition from a developmentally arrested mature oocyte to a developing embryo requires a series of highly conserved events, collectively known as egg activation. All of these events are preceded by a ubiquitous rise of intracellular calcium, which results from influx of external calcium and/or calcium release from internal storage. In Drosophila, this calcium rise initiates from the pole(s) of the oocyte by influx of external calcium in response to mechanical triggers. It is thought to trigger calcium responsive kinases and/or phosphatases, which in turn alter the oocyte phospho-proteome to initiate downstream events. Recent studies revealed that external calcium enters the activating Drosophila oocyte through Trpm channels, a feature conserved in mouse. The local entry of calcium ra

SUBMITTER: Hu Q 

PROVIDER: S-EPMC7594917 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature