Prediction and evolution of B cell epitopes of surface protein in SARS-CoV-2.

ABSTRACT:

Background

In order to obtain antibodies that recognize natural proteins, it is possible to predict the antigenic determinants of natural proteins, which are eventually embodied as polypeptides. The polypeptides can be coupled with corresponding vectors to stimulate the immune system to produce corresponding antibodies, which is also a simple and effective vaccine development method. The discovery of epitopes is helpful to the development of SARS-CoV-2 vaccine.

Methods

The analyses were related to epitopes on 3 proteins, including spike (S), envelope (E) and membrane (M) proteins, which are located on the lipid envelope of the SARS-CoV-2. Based on the NCBI Reference Sequence: NC_045512.2, the conformational and linear B cell epitopes of the surface protein were predicted sep

SUBMITTER: Lon JR 

PROVIDER: S-EPMC7594941 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature