IP-10 and MCP-1 as biomarkers associated with disease severity of COVID-19.

ABSTRACT:

Background

COVID-19 is a viral respiratory disease caused by the severe acute respiratory syndrome-Coronavirus type 2 (SARS-CoV-2). Patients with this disease may be more prone to venous or arterial thrombosis because of the activation of many factors involved in it, including inflammation, platelet activation and endothelial dysfunction. Interferon gamma inducible protein-10 (IP-10), monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein 1-alpha (MIP1α) are cytokines related to thrombosis. Therefore, this study focused on these three indicators in COVID-19, with the hope to find biomarkers that are associated with patients' outcome.

Methods

This is a retrospective single-center study involving 74 severe and critically ill COVID-19 patients recruited

SUBMITTER: Chen Y 

PROVIDER: S-EPMC7594996 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature