Design, synthesis and evaluation of a tripodal receptor for phosphatidylinositol phosphates.

ABSTRACT: Phosphatidylinositol phosphates (PIPs) are membrane phospholipids that play crucial roles in a wide range of cellular processes. Their function is dictated by the number and positions of the phosphate groups in the inositol ring (with seven different PIPs being active in the cell). Therefore, there is significant interest in developing small-molecule receptors that can bind selectively to these species and in doing so affect their cellular function or be the basis for molecular probes. However, to date there are very few examples of such molecular receptors. Towards this aim, herein we report a novel tripodal molecule that acts as receptor for mono- and bis-phosphorylated PIPs in a cell free environment. To assess their affinity to PIPs we have developed a new cell free assay based on the

SUBMITTER: Reeh K 

PROVIDER: S-EPMC7595110 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature