Dynamic transcriptional response of Saccharomyces cerevisiae cells to copper.

ABSTRACT: Copper is a crucial trace element for all living systems and any deficiency in copper homeostasis leads to the development of severe diseases in humans. The observation of extensive evolutionary conservation in copper homeostatic systems between human and Saccharomyces cerevisiae made this organism a suitable model organism for elucidating molecular mechanisms of copper transport and homeostasis. In this study, the dynamic transcriptional response of both the reference strain and homozygous deletion mutant strain of CCC2, which encodes a Cu²⁺-transporting P-type ATPase, were investigated following the introduction of copper impulse to reach a copper concentration which was shown to improve the respiration capacity of CCC2 deletion mutants. The analysis of data by using different

SUBMITTER: Oc S 

PROVIDER: S-EPMC7595141 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature