Probing coordinated co-culture cancer related motility through differential micro-compartmentalized elastic substrates.

ABSTRACT: Cell development and behavior are driven by internal genetic programming, but the external microenvironment is increasingly recognized as a significant factor in cell differentiation, migration, and in the case of cancer, metastatic progression. Yet it remains unclear how the microenvironment influences cell processes, especially when examining cell motility. One factor that affects cell motility is cell mechanics, which is known to be related to substrate stiffness. Examining how cells interact with each other in response to mechanically differential substrates would allow an increased understanding of their coordinated cell motility. In order to probe the effect of substrate stiffness on tumor related cells in greater detail, we created hard-soft-hard (HSH) polydimethylsiloxane (PDMS) su

SUBMITTER: Chou SY 

PROVIDER: S-EPMC7595178 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature