Neutrophil extracellular trap components and myocardial recovery in post-ischemic acute heart failure.

ABSTRACT:

Objective

The role of neutrophil extracellular traps (NETs) in acute heart failure is unknown. We recently showed that interleukin 8, a putative NETs stimulator, was associated with myocardial recovery in acute heart failure complicating ST-elevation myocardial infarction (STEMI). In this exploratory post-hoc study, we aimed to investigate the role of NETs components in relation to myocardial function and interleukin 8 in STEMI patients with symptomatic acute heart failure.

Methods

In 61 STEMI patients developing acute heart failure within 48 hours of successful revascularization, wall motion score index (WMSI), global longitudinal strain (GLS) and left ventricular ejection fraction (LVEF) were assessed by echocardiography at baseline and on day 5. Blood drawn at baseline an

SUBMITTER: Langseth MS 

PROVIDER: S-EPMC7595325 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature