Characterizing poroelasticity of biological tissues by spherical indentation: an improved theory for large relaxation.

ABSTRACT: Flow of fluids within biological tissues often meets with resistance that causes a rate- and size-dependent material behavior known as poroelasticity. Characterizing poroelasticity can provide insight into a broad range of physiological functions, and is done qualitatively in the clinic by palpation. Indentation has been widely used for characterizing poroelasticity of soft materials, where quantitative interpretation of indentation requires a model of the underlying physics, and such existing models are well established for cases of small strain and modest force relaxation. We showed here that existing models are inadequate for large relaxation, where the force on the indenter at a prescribed depth at long-time scale drops to below half of the initially peak force (i.e., F(0

SUBMITTER: Wang M 

PROVIDER: S-EPMC7595329 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature