Transgenic expression of human C19MC miRNAs impacts placental morphogenesis.

ABSTRACT:

Introduction

The chromosome 19 miRNA cluster (C19MC) encodes a large family of microRNAs (miRNAs) that are abundantly expressed in the placenta of higher primates and also in certain cancers. In the placenta, miRNAs from this cluster account for nearly 40% of all miRNAs present in trophoblasts. However, the function of these miRNAs in the placenta remains poorly understood. Recent observations reveal a role for these miRNAs in cell migration, and suggest that they are involved in the development and function of the human placenta. Here, we examine the placenta in transgenic mice expressing the human C19MC miRNAs.

Methods

We produced transgenic mice using pronuclear microinjection of a bacterial artificial chromosome plasmid carrying the entire human C19MC locus and derived a

SUBMITTER: Mouillet JF 

PROVIDER: S-EPMC7595355 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature