Tumor-infiltrating TNFRSF9⁺ CD8⁺ T cells define different subsets of clear cell renal cell carcinoma with prognosis and immunotherapeutic response.

ABSTRACT:

Objectives

Tumor necrosis receptor super family (TNFRSF) plays an important role in regulating the function of CD8⁺ T cells. In this study, we explored the clinical significance and immune profile of TNFRSF9⁺ CD8⁺ T cells in clear cell renal cell carcinoma (ccRCC).

Methods

The infiltration of immune cells was determined by immunohistochemistry in ZS cohort from our hospital and their prognostic value was further determined by Cox regression. Functional status of CD8⁺ T cells in ccRCC was determined by flow cytometry in 29 fresh tumor samples. In silico analysis on a TCGA cohort and other datasets was performed to further demonstrate our findings.

Results

High TNFRSF9⁺ CD8⁺ T cells infiltration was assoc

SUBMITTER: Li Y 

PROVIDER: S-EPMC7595587 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature