Replicated umbilical cord blood DNA methylation loci associated with gestational age at birth.

ABSTRACT: DNA methylation is highly sensitive to in utero perturbations and has an established role in both embryonic development and regulation of gene expression. The foetal genetic component has been previously shown to contribute significantly to the timing of birth, yet little is known about the identity and behaviour of individual genes. The aim of this study was to test the extent genome-wide DNA methylation levels in umbilical cord blood were associated with gestational age at birth (GA). Findings were validated in an independent sample and evidence for the regulation of gene expression was evaluated for cis gene relationships in specimens with multi-omic data. Genome-wide DNA methylation, measured by the Illumina Infinium Human Methylation 450 K BeadChip, was associated with G

SUBMITTER: York TP 

PROVIDER: S-EPMC7595591 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature