Regulatory approval of photoimmunotherapy: photodynamic therapy that induces immunogenic cell death.
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ABSTRACT:
SUBMITTER: Gomes-da-Silva LC
PROVIDER: S-EPMC7595598 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
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Regulatory approval of photoimmunotherapy: photodynamic therapy that induces immunogenic cell death.
Gomes-da-Silva Lígia C LC Kepp Oliver O Kroemer Guido G
Oncoimmunology 20201027 1
In September 2020, the Japanese government approved cetuximab saratolacan (previously known as RM-1929, commercial name: Akalux) for the treatment of unresectable locally advanced or recurrent head and neck cancer. Cetuximab saratolacan is a chemical conjugate of the photosensitizer IR700 with cetuximab, which targets EGFR. The treatment consists in the intravenous injection of cetuximab saratolacan, which binds to head and neck cancer cells expressing high levels of EGFR, followed by illuminati ...[more]
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