The DNA methylation landscape of human cancer organoids available at the American type culture collection.

ABSTRACT: One caveat in cancer research is the dependence of certain experimental systems that might not really reflect the properties of the primary tumours. The recent irruption of 3D cultured cells termed organoids could render a better representation of the original tumour sample. However, every laboratory has its own protocol and tissue-provider to establish these cancer models, preventing further dissemination and validation of the obtained data. To address this problem, the Human Cancer Models Initiative (HCMI) has selected the American Type Culture Collection (ATCC) to make available organoid models to the scientific community. In this regard, no epigenetic information is available for these samples and, overall, the DNA methylation profiles of human cancer organoids are largely unknown. Her

SUBMITTER: Joshi R 

PROVIDER: S-EPMC7595613 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature