Smoothened receptor signaling regulates the developmental shift of GABA polarity in rat somatosensory cortex.

ABSTRACT: Sonic hedgehog (Shh) and its patched-smoothened receptor complex control a variety of functions in the developing central nervous system, such as neural cell proliferation and differentiation. Recently, Shh signaling components have been found to be expressed at the synaptic level in the postnatal brain, suggesting a potential role in the regulation of synaptic transmission. Using in utero electroporation of constitutively active and negative-phenotype forms of the Shh signal transducer smoothened (Smo), we studied the role of Smo signaling in the development and maturation of GABAergic transmission in the somatosensory cortex. Our results show that enhancing Smo activity during development accelerates the shift from depolarizing to hyperpolarizing GABA in a manner dependent on functional

SUBMITTER: Delmotte Q 

PROVIDER: S-EPMC7595691 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature