M5UPred: A Web Server for the Prediction of RNA 5-Methyluridine Sites from Sequences.

ABSTRACT: As one of the widely occurring RNA modifications, 5-methyluridine (m⁵U) has recently been shown to play critical roles in various biological functions and disease pathogenesis, such as under stress response and during breast cancer development. Precise identification of m⁵U sites on RNA is vital for the understanding of the regulatory mechanisms of RNA life. We present here m5UPred, the first web server for in silico identification of m⁵U sites from the primary sequences of RNA. Built upon the support vector machine (SVM) algorithm and the biochemical encoding scheme, m5UPred achieved reasonable prediction performance with the area under the receiver operating characteristic curve (AUC) greater than 0.954 by 5-fold cross-validation and indepen

SUBMITTER: Jiang J 

PROVIDER: S-EPMC7595847 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature