Clinical Experience of Bevacizumab for Radiation Necrosis in Patients with Brain Metastasis.

ABSTRACT:

Background

As the application of radiotherapy to brain metastasis (BM) increases, the incidence of radiation necrosis (RN) as a late toxicity of radiotherapy also increases. However, no specific treatment for RN is indicated except long-term steroids. Here, we summarize the clinical results of bevacizumab (BEV) for RN.

Methods

Ten patients with RN who were treated with BEV monotherapy (7 mg/kg) were retrospectively reviewed. RN diagnosis was made using MRI with or without perfusion MRI. Radiological response was based on Response Assessment in Neuro-Oncology criteria for BM. The initial response was observed after 2 cycles every 2 weeks, and maintenance observed after 3 cycles every 3-6 weeks of increasing length intervals.

Results

The initial response of gadolinium (

SUBMITTER: Park M 

PROVIDER: S-EPMC7595848 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature