Hsa_circ_0023642 promotes proliferation, invasion, and migration of gastric cancer by sponging microRNA-223.

ABSTRACT:

Background

Circular RNAs (circRNAs) have a closed-loop structure and are associated with various cellular biological processes, including carcinogenesis and cancer development. However, our knowledge of circRNAs in gastric cancer (GC) remains limited. Thus, this study aimed to investigate the role and underlying molecular mechanisms of hsa_circ_0023642 in GC.

Materials and methods

Bioinformatic analysis revealed that hsa_circ_0023642 was upregulated in GC. Chromogenic in situ hybridization (CISH) chips was used to explore the relationship between the expression of hsa_circ_0023642 and the malignant degree, clinical stage, and prognosis of patients with GC. The role of hsa_circ_0023642 in GC was assessed in vitro, and biotin-coupled RNA pull-down was conducted to evaluate the

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC7595887 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature