Screening and identification of biomarkers associated with the diagnosis and prognosis of lung adenocarcinoma.

ABSTRACT:

Background

In this study, we aimed to identify the pathogenesis and prognostic biomarkers of lung adenocarcinoma (LUAD).

Methods

Differentially expressed mRNAs (DEmRNAs) and single nucleotide polymorphism (SNP) mutant genes were screened. In addition, enrichment and protein-protein interaction (PPI) network analyses of the SNP-mutated genes were performed. Thereafter, the correlation between gene mutation and expression was analyzed. Finally, the mutated genes associated with LUAD prognosis were validated on the basis of The Cancer Genome Atlas (TCGA) database.

Results

A total of 2502 DEmRNAs were initially screened in this study. We identified 756 SNP-mutated genes from more than 30 cases. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed t

SUBMITTER: Wang Y 

PROVIDER: S-EPMC7595917 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature