Day-to-day variability of [⁶⁸Ga]Ga-PSMA-11 accumulation in primary prostate cancer: effects on tracer uptake and visual interpretation.

ABSTRACT:

Purpose

Prostate-specific membrane antigen (PSMA) agents, such as [⁶⁸Ga]Ga-PSMA-11, have an unprecedented accuracy in staging prostate cancer (PCa) and detecting disease recurrence. PSMA PET/CT may also be used for response monitoring by displaying molecular changes, instead of morphological changes alone. However, there are still limited data available on the variability in biodistribution and intra-prostatic uptake of PSMA targeting radiotracers. Therefore, the aim of this study was to assess the repeatability of [⁶⁸Ga]Ga-PSMA-11 uptake in primary PCa patients in a 4-week interval.

Methods

Twenty-four primary PCa patients were prospectively included, who already were scheduled for [⁶⁸Ga]Ga-PSMA-11 PET/CT scan on clinical indication (≥ cT3,

SUBMITTER: Olde Heuvel J 

PROVIDER: S-EPMC7596127 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature